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熱烈恭喜世界各地的化學(xué)研究者使用Syrris流動化學(xué)系統(tǒng)，并在世界雜志上發(fā)表了50多篇文章。

 隨著科學(xué)技術(shù)的不斷發(fā)展，推動著更加先進(jìn)儀器的問世，繼而為科技的發(fā)展如虎添翼。流動化學(xué)的興起是近幾年來化學(xué)領(lǐng)域zui大的一次變革，隨著流動化學(xué)的、安全、清潔等優(yōu)勢逐漸被研究者認(rèn)可，越來越多的研究者開始選擇用流動化學(xué)來做反應(yīng)。
 
以下是2006年-2013年Syrris流動化學(xué)系統(tǒng)助力研究者們發(fā)表的文章，且呈逐年增多的趨勢。
2013
Continuous Flow Synthesis of n?Alkyl Chlorides in a High-Temperature Microreactor Environment
Benedikt Reichart, Guenter Tekautz, and C. Oliver Kappe*
Org. Process Res. Dev., 2013, 17 （1）, 152–157.
Continuous-Flow Microfluidic Electrochemical Synthesis: Investigating a New Tool for Oxidative Chemistry
Gregory P. Roth*, Romain Stalder, Toby R. Long, Daryl R. Sauer and Stevan W. Djuric
J. Flow Chem., 2013, In Press.
Hydrogen-Free Alkene Reduction in Continuous Flow
Andrew S. Kleinke, Timothy F. Jamison
Org. Lett., 2013, 15 （3）, 710–713.
Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions
Laura Carroccia, Biagia Musio, Leonardo Degennaro, Giuseppe Romanazzi and Renzo Luisi*
J. Flow Chem., 2013, In Press.
A comprehensive study on the activity and deactivation of immobilised Lecitase Ultra in esterifications of food waste streams to monoacylglycerols
Karen M. Gonçalves, Felipe K. Sutili, Ivaldo I. Júnior, Marcella C. Flores, Leandro Soter de Mariz e Miranda, Ivana C.R. Leal, Yraima Cordeiro, Rafael Luque* and Rodrigo Octavio M. Alves de Souza*
ChemSusChem., 2013, 6 （5）, 872-9.
Continuous-Flow Synthesis of Adipic Acid from Cyclohexene Using Hydrogen Peroxide in High-Temperature Explosive Regimes
Dr. Markus Damm, Bernhard Gutmann, Prof. Dr. C. Oliver Kappe
ChemSusChem, 2013, In Press.
Biocatalyzed Acetins Production Under Continuous-Flow Conditions: Valorization of Glycerol Derived From Biodiesel Industry
Ingrid C. R. Costa, Ivaldo Itabaiana Jr., Marcella C. Flores, Ana Clara Lourenço, Selma G. F. Leite, Leandro S. de M. e Miranda, Ivana C. R. Leal and Rodrigo O. M. A. de Souza*
J. Flow Chem., 2013, In Press.
Nickel nanocrystals: fast synthesis of cubes, pyramids and tetrapods
Meital Shviro and David Zitoun*
RSC Advances, 2013, 3, 1380.
Biocatalytic preparation of dichloropropyl acrylates. Application to the synthesis of poly（dichloropropyl acrylates）
Yara-Varón Edinson, Eras Joli Jordi, Torres Mercè, Balcells Mercèa, Villorbina Gemma, Canela-Garayoa Ramon
Journal of Molecular Catalysis B: Enzymatic, 92, （2013）, 7– 13.
Continuous Flow Valorization of Fatty Acid Waste Using Silica-Immobilized Lipases
Ivaldo Itabaiana Jr, Felipe K. Sutili, Selma G. F. Leite, Karen M. Goncalves, Yraima Cordeiro, Ivana C. R. Leal, Leandro S. M. Miranda, Manuel Ojeda, Rafael Luque, Rodrigo O. M. A. de Souza
Green Chem., 2013, 15, 518-524.
Greening heterogeneous catalysis for fine chemicals
Valerica Pandarus, Rosaria Ciriminna, François Béland, Genevieve Gingras, Maxime Drobot,
Omar Jina, Mario Pagliaro
Tetrahedron Letters, 54 （2013） 1129–1132.
Kinetic resolution of 5H-pyrrolo[1,2-a]imidazol-7-ol, 6,7-dihydro under continuous flow conditions: An intermediate for chiral ionic liquids synthesis
Amanda S. De Miranda, Juliana C. Gomes, Manoel T. Rodrigues Jr., Ingrid C.R. Costa, Wanda P. Almeida, Raquel de O. Lopes, Leandro S.M. Miranda, Fernando Coelho, Rodrigo O.M.A. de Souza
Journal of Molecular Catalysis B: Enzymatic 91 （2013） 77– 80.
Ethyl acetate as an acyl donor in the continuous flow kinetic resolution of （±）-1-phenylethylamine catalyzed by lipases
Amanda S. de Miranda, Leandro S. M. Miranda and Rodrigo O. M. A. de Souza*
Org. Biomol. Chem., 2013, 11, 3332.
Kinetic resolution of a precursor for myo-inositol phosphates under continuous flow conditions
Evelin A. Manoel, Karla C. Pais, Marcella C. Flores, Leandro Soter de M. e Miranda, Maria Alice Zarur Coelho, Alessandro B.C. Simas, Denise M.G. Freire, Rodrigo Octavio M.A. de Souza
Journal of Molecular Catalysis B: Enzymatic 87 （2013） 139–143.
Micro-continuous flow synthesis of gold nanoparticles and integrated deposition on suspended sheets of graphene oxide
Marek Wojnicki, Magdalena Luty-B?ocho, Justyna Grzonka, Krzysztof Pac?awski, Krzysztof J. Kurzyd?owski, Krzysztof Fitzner
Chemical Engineering Journal, 225, （2013）, 597–606.
Lipase-catalyzed esterification of steric hindered fructose derivative by continuous flow and batch conditions
Felipe K. Sutili, Halliny S. Ruela, Selma G.F. Leite, Leandro S. de M. Miranda, Ivana C.R. Leal, Rodrigo O.M.A. de Souza
Journal of Molecular Catalysis B: Enzymatic 85– 86 （2013） 37– 42.
Lipase-catalyzed synthesis of secondary glucose esters under continuous flow conditions
Halliny S. Ruela, Felipe K. Sutili, Ivana C. R. Leal, Nakedia M. F. Carvalho, Leandro S. M. Miranda and Rodrigo O. M. A. de Souza
Eur. J. Lipid Sci. Technol. 2013, 115, 464–467.
The synthesis of platinum nanoparticles and their deposition on the active carbon fibers in one microreactor cycle
Magdalena Luty-B?ocho, Marek Wojnicki, Krzysztof Pac?awski, Krzysztof Fitzner
Chemical Engineering Journal, 226, （2013）, 46–51.
2012
Continuous stream processing: a prototype magnetic field induced flow mixer
Peter Koos, Duncan L. Browne and Steven V. Ley *
Green Process Synth 1 （2012）: 11–18.
Silver nanowires and nanoparticles from a millifluidic reactor: application to metal assisted silicon etching
Ronen Gottesman, Alex Tangy, Ilan Oussadon and David Zitoun*
New J. Chem., 2012, 36, 2456–2459.
Synthesis of poly（ethyl acrylate-co-allyl acrylates） from acrylate mixtures prepared by a continuous solvent-free enzymatic process
Edinson Yara-Varo´n, Jordi Eras Joli, Merce Balcells, Merce Torres and Ramon Canela-Garayoa*
RSC Advances, 2012, 2, 9230–9236.
TEMPO-Mediated Electro-oxidation of Primary and Secondary Alcohols in a Microfluidic Electrolytic Cell
Joseph T. Hill-Cousins, Jekaterina Kuleshova, Robert A. Green, Peter R. Birkin, Derek Pletcher, Toby J. Underwood, Stuart G. Leach and Richard C. D. Brown*
ChemSusChem, 2012, 5, 326–331.
Liquid-Liquid Two-phase Flow Patterns in a Serpentine Microchannel
P. S. Sarkar, K.K. Singh, K. T. Shenoy, A. Sinha, Hanmanth Rao, and Sandip Kumar Ghosh
Ind. Eng. Chem. Res., 2012, 51 （13）, 5056-5066.
The methoxylation of N-formylpyrrolidine in a microfluidic electrolysis cell for routine synthesis
Jekaterina Kuleshova, Joseph T. Hill-Cousins, Peter R. Birkin, Richard C.D. Brown, Derek Pletcher, Toby J. Underwood
Electrochimica Acta, 69, （2012）, 197–202.
Copper（I）-Catalyzed Azide–Alkyne Cycloadditions in Microflow: Catalyst Activity, High-Temperature Operation, and an Integrated Continuous Copper Scavenging UnitAlvaro Carlos Varas, Timothy Noel, Qi Wang, and Volker Hessel*
ChemSusChem, 2012, Vol. 5, Issue 9, 1703-1707.
2011
An Automated Process for a Sequential Heterocycle Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-（Thiazol-2-yl）-3,4-Dihydropyrimidin-2（111）-ones
Nicholas Pagano, Ananda Herath and Nicholas D. P. Cosford*
J. Flow. Chem., 2011, I, 28-31.
Effectiveness of mouse minute virus inactivation by high temperature short time
treatment technology: A statistical assessment
Marie Murphy, Guillermo Miro Quesada, Dayue Chen*
Biologicals, 39, （2011）, 438-443.
Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor
Laetitia J. Martin,* Andreas L. Marzinzik, Steven V. Ley, and Ian R. Baxendale
Organic Letters, 2011, Vol. 13, No. 2, 320-323.
Continuous-flow reactor–based synthesis of carbohydrate and dihydrolipoic acid–capped quantum dots
Paola Laurino, Raghavendra Kikkeri and Peter H Seeberger*
Nature Protocols, Vol. 6, No. 8, 2011, 1209-1220.
Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline
Xacobe C. Cambeiro, Rafael Martín-Rapún, Pedro O. Miranda, Sonia Sayalero, Esther Alza, Patricia Llanes and Miquel A. Pericàs*
Beilstein J. Org. Chem. 2011, 7, 1486–1493.
Enhanced catalysis under flow conditions using SiliaBond functionalized silica gels
Valerica Pandarus, Genevieve Gingras, Francois Beland, Rosaria Ciriminna and Mario Pagliaro
Catal. Sci. Technol., 2011, 1, 1600-1604.
The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous-Flow Processes
Dr. Toma N. Glasnov*, Prof. Dr. C. Oliver Kappe*
Chemistry - A European Journal, 2011, Volume 17, Issue 43, pages 11956–11968.
2010
Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles
Ananda Herath, Russell Dahl, and Nicholas D. P. Cosford*
Organic Letters 2010 Vol. 12, No. 3 412-415.
Automated Generation and Reactions of 3-Hydroxymethylindoles in
Continuous-Flow Microreactors
Thomas Tricotet and Donal F. O_Shea*
Chem. Eur. J. 2010, 16, 6678 – 6686
One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert-Butyl Esters
Ananda Herath and Nicholas D. P. Cosford*
Organic Letters, 2010, 12 （22）, 5182-5185.
Continuous flow processing from microreactors to mesoscale: the
Bohlmann–Rahtz cyclodehydration reaction
Mark C. Bagley,* Vincenzo Fusillo, Robert L. Jenkins, M. Caterina Lubinu and Christopher Mason
Org. Biomol. Chem., 2010, , 2245–2251
Little Artifices of Huge Libraries: Secrets of Parallel Liquid-Phase SynthesisE. V. Babaev
Russian Journal of General Chemistry, 2010, Vol. 80, No. 12 pp. 2607–2616.
Microreactor Technology as an Efficient Tool for Multicomponent Reactions
Ana Cukalovic, Jean-Christophe M.R. Monbaliu, and Christian V. Stevens
Top Heterocycl Chem （2010） 23: 161–198.
2009
A Convenient and Stable Synthon for Ethyl Azide and Its Evaluation in a
[3 + 2]-Cycloaddition Reaction under Continuous-Flow Conditions
Rob Tinder, Roger Farr,† Richard Heid, Ralph Zhao, Randy S. Rarig, Jr.,and Thomas Storz*,
Organic Process Research & Development 2009, 13, 1401–1406.
Gold Nanoparticles Synthesis in a Flow Microreactor Stabilized with a PVA （polyvinyl alcohol）
M. Wojnicki K. Pac?awski, M. Luty-B?ocho, K. Fitzner, P. Oakley, A. Stretton
Rudy Metale, 12, （2009）, 848-851.
Facile, Fast and Safe Process Development of Nitration and Bromination Reactions Using Continuous Flow Reactors
Jacques Pelleter* and Fabrice Renaud
Organic Process Research & Development, 2009, 13, 698–705.
Conditions of the microdroplets formation in microreactors
M. Wojnicki K. Pac?awski, M. Luty-B?ocho, K. Fitzner, P. Oakley, A. Stretton
Rudy Metale, 9, （2009）, 528-541.
2008
Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence
Daniel Grant, Russell Dahl, and Nicholas D. P. Cosford*
J. Org. Chem., 2008, 73 （18）, 7219-7223.
Evaluation of Microfluidics Reactor Technology on the Kinetics of Virus Inactivation
Mark R. Bailey, Dayue Chen, Warren R. Emery, Peter K. Lambooy, Juliana Nolting, Michelle T. Quertinmont, and Parviz A. Shamlou
Biotechnology and Bioengineering, 2008, Vol. 99, Issue 6, 1384-1391.
Determination of log D via Automated Microfluidic Liquid-Liquid Extraction
Muhammad Alimuddin, Daniel Grant, Daryl Bulloch, Noelle Lee, Martin Peacock, and Russell Dahl
J. Med. Chem., 2008, 51 （16）, 5140-5142.
Continuous Biodiesel Production with Continuous Liquid-Liquid Extraction and Online MS Analysis
Elizabeth Crawford, Russell Dahl, Douglas Duquette,1 Daniel Grant,4 Richard Gray, Brian Musselman, Martin Peacock, James Petersen
Fuel Chemistry Division Preprints 2008
Fluorination reactions in microreactors
Tomas Gustafsson, Ryan Gilmour and Peter H. Seeberger*
Chem. Commun., 2008, 3022–3024.
2007
[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted
1,2,3-triazoles in a modular flow reactor
Christopher D. Smith, Ian R. Baxendale, Steve Lanners, John J. Hayward, Stephen C. Smith and
Steven V. Ley*
Org. Biomol. Chem., 2007, , 1559–1561. Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
Christopher D. Smith, Ian R. Baxendale, Geoffrey K. Tranmer, Marcus Baumann, Stephen C. Smith,Russell A. Lewthwaite and Steven V. Ley*
Org. Biomol. Chem., 2007, , 1562–1568.
Mesoscale Flow Chemistry: A Plug-Flow Approach to Reaction Optimisation
Rob C. Wheeler,* Otman Benali, Martyn Deal, Elizabeth Farrant, Simon J. F. MacDonald, and Brian H. Warrington
Organic Process Research & Development, 2007, 11, 704710.
2006
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
Ian R. Baxendale, Jon Deeley, Charlotte M. Griffiths-Jones, Steven V. Ley,* Steen Saaby and
Geoffrey K. Tranmer
Chem. Commun., 2006, 2566–2568.
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Ian R. Baxendale, Steven V. Ley,* Christopher D. Smith and Geoffrey K. Tranmer
Chem. Commun., 2006, 4835–4837.